Protein name:
Protein S100-A9 ;
Alternative:
Calgranulin-B ;BEE22 ;S100 calcium-binding protein A9 ;Neutrophil cytosolic 23 kDa protein (p23) ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Homodimer. Heterotetramer with S100A8. Component of the heterotetrameric calprotectin complex containing two copies each of S100A8 and S100A9. Interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner. Heterotetrameric calprotectin interacts with ANXA6 and associates with tubulin filaments in activated monocytes. May interact with components of the intermediate filaments in monocytes and epithelial cells. The homodimer interacts with AGER and with the heterodimeric complex formed by TLR4 and LY96 in the presence of calcium and/or zinc ions. The homodimer binds quinoline-3-carboxamides in the presence of calcium and/or zinc ions.
Function:
Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). Promotes tubulin polymerization when unphosphorylated. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions.
Subcellular Location:
Secreted
Cytoplasm
Cytoplasm
cytoskeleton
Cell membrane
Peripheral membrane protein
Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes.
Protein Attributes:
50:
MEDKMSQMES | SIETIINIFH | QYSVRLGHYD | TLIQKEFKQL | VQKELPNFLK |
100:
KQKKNEAAIN | EIMEDLDTNV | DKQLSFEEFI | MLVARLTVAS | HEEMHNTAPP |
150:
GQGHRHGPGY | GKGGSGSCSG | QGSPDQGSHD | LGSHGHGHGH | SHGGHGHSHG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
Rabbit
ELISA Kit for Bovine Protein S100-A9
ELISA Kit for Bovine Protein S100-A9
ELISA Kit for Bovine Protein S100-A9
ELISA Kit for Bovine Protein S100-A9
ELISA Kit for Bovine Protein S100-A9
CLIA Kit for Bovine Protein S100-A9
CLIA Kit for Bovine Protein S100-A9
CLIA Kit for Bovine Protein S100-A9
CLIA Kit for Bovine Protein S100-A9
CLIA Kit for Bovine Protein S100-A9
Polyclonal Antibody for Bovine Protein S100-A9
Polyclonal Antibody for Bovine Protein S100-A9
Polyclonal Antibody for Bovine Protein S100-A9
Polyclonal Antibody for Bovine Protein S100-A9
Polyclonal Antibody for Bovine Protein S100-A9
Monoclonal Antibody for Bovine Protein S100-A9
Monoclonal Antibody for Bovine Protein S100-A9
Monoclonal Antibody for Bovine Protein S100-A9
Monoclonal Antibody for Bovine Protein S100-A9
Monoclonal Antibody for Bovine Protein S100-A9
Protein for Bovine Protein S100-A9
Protein for Bovine Protein S100-A9
Protein for Bovine Protein S100-A9
Protein for Bovine Protein S100-A9
Protein for Bovine Protein S100-A9
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Testis .
2.
"Nuclear proteins of the bovine esophageal epithelium. I. Monoclonal antibody W2 specifically reacts with condensed nuclei of differentiated superficial cells."
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Lin C.-Y.
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Lai M.-L.
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Liu C.H.L.
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Lo H.-J.
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Wang M.-E.
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Chen L.B.
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Chen W.-T.
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Ip W.
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Lin D.C.
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Lin J.J.-C.
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Sun T.-T.
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Wang E.
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Wang J.L.
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Wu R.
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Wu C.-W.
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Chien S.
more...
J. Cell Sci.104:237-247(1993)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 5-126
tissue :
Esophageal epithelium .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 8-60
tissue :
Neutrophil .